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Mechanistic insights into the recognition of 5-methylcytosine oxidation derivatives by the SUVH5 SRA domain

5-Methylcytosine (5 mC) is associated with epigenetic gene silencing in mammals and plants. 5 mC is consecutively oxidized to 5-hydroxymethylcytosine (5 hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by ten-eleven translocation enzymes. We performed binding and structural studies to inve...

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Detalles Bibliográficos
Autores principales:	Rajakumara, Eerappa, Nakarakanti, Naveen Kumar, Nivya, M. Angel, Satish, Mutyala
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740795/ https://www.ncbi.nlm.nih.gov/pubmed/26841909 http://dx.doi.org/10.1038/srep20161

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