Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum

DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the ‘epigenetic clock'. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant (P<5.0 × 10(−8)) SNPs in two loci: 2p22.1 (inside gene D...

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Detalles Bibliográficos
Autores principales: Lu, Ake T., Hannon, Eilis, Levine, Morgan E., Hao, Ke, Crimmins, Eileen M., Lunnon, Katie, Kozlenkov, Alexey, Mill, Jonathan, Dracheva, Stella, Horvath, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740877/
https://www.ncbi.nlm.nih.gov/pubmed/26830004
http://dx.doi.org/10.1038/ncomms10561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740877/
https://www.ncbi.nlm.nih.gov/pubmed/26830004
http://dx.doi.org/10.1038/ncomms10561

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