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Reproducibility of SNV-calling in multiple sequencing runs from single tumors

We examined 55 technical sequencing replicates of Glioblastoma multiforme (GBM) tumors from The Cancer Genome Atlas (TCGA) to ascertain the degree of repeatability in calling single-nucleotide variants (SNVs). We used the same mutation-calling pipeline on all pairs of samples, and we measured the ex...

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Detalles Bibliográficos
Autores principales:	Derryberry, Dakota Z., Cowperthwaite, Matthew C., Wilke, Claus O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2016
Materias:	Bioinformatics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741064/ https://www.ncbi.nlm.nih.gov/pubmed/26855855 http://dx.doi.org/10.7717/peerj.1508

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