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Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma
Purpose: To evaluate the effect of 0.125% verapamil and 0.5% diltiazem eye drops on intraocular pressure (IOP) in steroid-induced glaucoma in rabbit eyes. Methods: A total of 18 rabbits with steroid-induced glaucoma were divided into three groups (A, B and C; n = 6 each). Right eyes in groups A, B a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Jaypee Brothers Medical Publishers
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741158/ https://www.ncbi.nlm.nih.gov/pubmed/26997802 http://dx.doi.org/10.5005/jp-journals-10008-1155 |
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author | Ganekal, Sunil Dorairaj, Syril Jhanji, Vishal Kudlu, Krishnaprasad |
author_facet | Ganekal, Sunil Dorairaj, Syril Jhanji, Vishal Kudlu, Krishnaprasad |
author_sort | Ganekal, Sunil |
collection | PubMed |
description | Purpose: To evaluate the effect of 0.125% verapamil and 0.5% diltiazem eye drops on intraocular pressure (IOP) in steroid-induced glaucoma in rabbit eyes. Methods: A total of 18 rabbits with steroid-induced glaucoma were divided into three groups (A, B and C; n = 6 each). Right eyes in groups A, B and C received 0.5% diltiazem, 0.125% verapamil and 0.5% timolol eye drops twice daily for 12 days, respectively; whereas, left eyes received distilled water. IOP was measured with Tono-pen XL at baseline, day 4, day 8, and day 12 of treatment. Results: Both 0.5% diltiazem and 0.125% verapamil eye drops significantly reduced IOP compared to control eyes (p < 0.05). Reduction of IOP by 0.5% diltiazem, 0.125% verapamil eye drops were comparable to 0.5% timolol. No surface toxicity or systemic side effects were noted during the study period. Conclusion: Calcium channel blockers, verapamil, and diltia-zem significantly reduced IOP in rabbiteyes. This group of drugs may have a potential role in treatment of glaucoma How to cite this article: Ganekal S, Dorairaj S, Jhanji V, Kudlu K. Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. J Current Glau Prac 2014;8(1):15-19. |
format | Online Article Text |
id | pubmed-4741158 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Jaypee Brothers Medical Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-47411582016-03-18 Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma Ganekal, Sunil Dorairaj, Syril Jhanji, Vishal Kudlu, Krishnaprasad J Curr Glaucoma Pract Original Research Purpose: To evaluate the effect of 0.125% verapamil and 0.5% diltiazem eye drops on intraocular pressure (IOP) in steroid-induced glaucoma in rabbit eyes. Methods: A total of 18 rabbits with steroid-induced glaucoma were divided into three groups (A, B and C; n = 6 each). Right eyes in groups A, B and C received 0.5% diltiazem, 0.125% verapamil and 0.5% timolol eye drops twice daily for 12 days, respectively; whereas, left eyes received distilled water. IOP was measured with Tono-pen XL at baseline, day 4, day 8, and day 12 of treatment. Results: Both 0.5% diltiazem and 0.125% verapamil eye drops significantly reduced IOP compared to control eyes (p < 0.05). Reduction of IOP by 0.5% diltiazem, 0.125% verapamil eye drops were comparable to 0.5% timolol. No surface toxicity or systemic side effects were noted during the study period. Conclusion: Calcium channel blockers, verapamil, and diltia-zem significantly reduced IOP in rabbiteyes. This group of drugs may have a potential role in treatment of glaucoma How to cite this article: Ganekal S, Dorairaj S, Jhanji V, Kudlu K. Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. J Current Glau Prac 2014;8(1):15-19. Jaypee Brothers Medical Publishers 2014 2014-01-16 /pmc/articles/PMC4741158/ /pubmed/26997802 http://dx.doi.org/10.5005/jp-journals-10008-1155 Text en Copyright © 2014; Jaypee Brothers Medical Publishers (P) Ltd. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Original Research Ganekal, Sunil Dorairaj, Syril Jhanji, Vishal Kudlu, Krishnaprasad Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma |
title | Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma |
title_full | Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma |
title_fullStr | Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma |
title_full_unstemmed | Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma |
title_short | Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma |
title_sort | effect of topical calcium channel blockers on intraocular pressure in steroid-induced glaucoma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741158/ https://www.ncbi.nlm.nih.gov/pubmed/26997802 http://dx.doi.org/10.5005/jp-journals-10008-1155 |
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