Cargando…

Gavage of D-Ribose induces Aβ-like deposits, Tau hyperphosphorylation as well as memory loss and anxiety-like behavior in mice

In addition to D-Glucose, D-Ribose is also abnormally elevated in the urine of type 2 diabetic patients, establishing a positive correlation between the concentration of uric D-Ribose and the severity of diabetes. Intraperitoneal injection of D-Ribose causes memory loss and brain inflammation in mic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Beibei, Wei, Yan, Wang, Yujing, Su, Tao, Zhou, Lei, Liu, Ying, He, Rongqiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741441/ https://www.ncbi.nlm.nih.gov/pubmed/26452037

Ejemplares similares

Ribosylation triggering Alzheimer’s disease-like Tau hyperphosphorylation via activation of CaMKII
por: Wei, Yan, et al.
Publicado: (2015)

Escitalopram attenuates β-amyloid-induced tau hyperphosphorylation in primary hippocampal neurons through the 5-HT(1A) receptor mediated Akt/GSK-3β pathway
por: Wang, Yan-Juan, et al.
Publicado: (2016)

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia
por: Biundo, Fabrizio, et al.
Publicado: (2016)

Synthetic Aβ peptides acquire prion-like properties in the brain
por: Xiao, Xiangzhu, et al.
Publicado: (2014)

Amyloid accumulation is a late event in sporadic Alzheimer's disease-like pathology in nontransgenic rats
por: Stefanova, Natalia A., et al.
Publicado: (2014)

Myelin injury induces axonal transport impairment but not AD-like pathology in the hippocampus of cuprizone-fed mice
por: Sun, Junjun, et al.
Publicado: (2016)

Dry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis
por: Park, Sung Wook, et al.
Publicado: (2017)

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin
por: Hu, Yu, et al.
Publicado: (2016)

Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer’s disease and other tauopathies
por: Florenzano, Fulvio, et al.
Publicado: (2017)

Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice
por: Bordeleau, Maude, et al.
Publicado: (2016)

Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells
por: Liu, Zhao, et al.
Publicado: (2016)

Crosstalk between insulin-like growth factor-1 and angiotensin-II in dopaminergic neurons and glial cells: role in neuroinflammation and aging
por: Rodriguez-Perez, Ana I., et al.
Publicado: (2016)

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins
por: Evangelisti, Camilla, et al.
Publicado: (2015)

A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1
por: Senthil, Kumar K.J., et al.
Publicado: (2016)

COX-2 metabolic products, the prostaglandin I(2) and F(2α), mediate the effects of TNF-α and Zn(2+) in stimulating the phosphorylation of Tau
por: Wang, Yue, et al.
Publicado: (2017)

Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline
por: Hines, Amelia D., et al.
Publicado: (2023)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

Rapid and simple detection of gero-suppressive agents
por: Darzynkiewicz, Zbigniew
Publicado: (2015)

WW domain-containing oxidoreductase in neuronal injury and neurological diseases
por: Chang, Hsin-Tzu, et al.
Publicado: (2014)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition
por: Rémond, Didier, et al.
Publicado: (2015)

Measuring refractive index distribution in the human eye lens
por: Pope, James M., et al.
Publicado: (2015)

Characterization and redox mechanism of asthma in the elderly
por: Zuo, Li, et al.
Publicado: (2016)

REM sleep behaviour disorder (RBD): risk for Parkinsonism and executive dysfunction in elderly
por: Lerche, Stefanie, et al.
Publicado: (2018)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

Reprogramming of energy metabolism as a driver of aging
por: Feng, Zhaoyang, et al.
Publicado: (2016)

The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling
por: Wang, Gang, et al.
Publicado: (2016)

Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer's disease
por: Chen, Jiu, et al.
Publicado: (2016)

Interferon-gamma deficiency protects against aging-related goblet cell loss
por: Volpe, Eugene A., et al.
Publicado: (2016)

To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss
por: Kam, Jaimie Hoh, et al.
Publicado: (2015)

Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis
por: Seidel, Philipp, et al.
Publicado: (2016)

Weight loss in the healthy elderly might be a non-cognitive sign of preclinical Alzheimer's disease
por: Jimenez, Amanda, et al.
Publicado: (2017)

Sex-specific autophagy modulation in osteoblastic lineage: a critical function to counteract bone loss in female
por: Camuzard, Olivier, et al.
Publicado: (2016)

Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1
por: D´Annunzio, Verónica, et al.
Publicado: (2016)

Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy
por: Zieger, Marina, et al.
Publicado: (2016)

Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice
por: Ma, Jing, et al.
Publicado: (2017)

Immunological memory to hyperphosphorylated tau in asymptomatic individuals
por: Pascual, Gabriel, et al.
Publicado: (2017)

The prion-like transmission of tau oligomers via exosomes
por: Jackson, Noel A., et al.
Publicado: (2022)

Iron Deposition Leads to Hyperphosphorylation of Tau and Disruption of Insulin Signaling
por: Wan, Wenbin, et al.
Publicado: (2019)

Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells
por: Løhr, Mille, et al.
Publicado: (2014)

Trafficking protein particle complex 6A delta (TRAPPC6AΔ) is an extracellular plaque-forming protein in the brain
por: Chang, Jean-Yun, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_hccdfqg31nes0ccfq8uesngj10