Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice

Cancer gene panels (CGPs) are already used in clinical practice to match tumor's genetic profile with available targeted therapies. We aimed to determine if CGPs could also be applied to estimate tumor mutational load and predict clinical benefit to PD-1 and CTLA-4 checkpoint blockade therapy....

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Detalles Bibliográficos
Autores principales: Campesato, Luís Felipe, Barroso-Sousa, Romualdo, Jimenez, Leandro, Correa, Bruna R., Sabbaga, Jorge, Hoff, Paulo M., Reis, Luiz F. L., Galante, Pedro Alexandre F., Camargo, Anamaria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741447/
https://www.ncbi.nlm.nih.gov/pubmed/26439694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741447/
https://www.ncbi.nlm.nih.gov/pubmed/26439694

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