STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation

The ubiquitin-specific protease USP7 stabilizes both Mdm2 and p53 by removing ubiquitins, hence playing an important enzymatic role in the p53-Mdm2 pathway. However, it is poorly understood how USP7 executes its dual-stabilization effect on Mdm2 and p53 in cellular context. Here, we report that STIP...

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Detalles Bibliográficos
Autores principales: Ye, Mao, Tang, Yani, Tang, Shijun, Liu, Jing, Wu, Kuangpei, Yao, Shan, Sun, Yang, Zhou, Lei, Deng, Tanggang, Chen, Ying, Huang, Chenghan, Tan, Weihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741485/
https://www.ncbi.nlm.nih.gov/pubmed/26460617

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