Skp1 in lung cancer: clinical significance and therapeutic efficacy of its small molecule inhibitors

Skp1 is an essential adaptor protein of the Skp1-Cul1-F-box protein complex and is able to stabilize the conformation of some ubiquitin E3 ligases. However, the role Skp1 plays during tumorigenesis remains unclear and Skp1-targeting agent is lacking. Here we showed that Skp1 was overexpressed in 36/...

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Detalles Bibliográficos
Autores principales: Liu, Yong-Qiang, Wang, Xiao-Lu, Cheng, Xin, Lu, Yong-Zhi, Wang, Gui-Zhen, Li, Xin-Chun, Zhang, Jian, Wen, Zhe-Sheng, Huang, Zhi-Liang, Gao, Qin-Lei, Yang, Li-Na, Cheng, Yong-Xian, Tao, Sheng-Ce, Liu, Jinsong, Zhou, Guang-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741501/
https://www.ncbi.nlm.nih.gov/pubmed/26474281

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