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Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation

Epidermal growth factor receptor (EGFR) is an oncogenic receptor tyrosine kinase. Canonically, the tyrosine kinase activity of EGFR is regulated by its extracellular ligands. However, ligand-independent activation of EGFR exists in certain cancer cells, and the underlying mechanism remains to be def...

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Detalles Bibliográficos
Autores principales:	Bollu, Lakshmi Reddy, Katreddy, Rajashekhara Reddy, Blessing, Alicia Marie, Pham, Nguyen, Zheng, Baohui, Wu, Xu, Weihua, Zhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741504/ https://www.ncbi.nlm.nih.gov/pubmed/26378037

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