Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells

Neurocognitive deficits are serious sequelae that follow cranial irradiation used to treat patients with medulloblastoma and other brain neoplasms. Cranial irradiation causes apoptosis in the subgranular zone of the hippocampus leading to cognitive deficits. Valproic acid (VPA) treatment protected h...

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Detalles Bibliográficos
Autores principales: Thotala, Dinesh, Karvas, Rowan M., Engelbach, John A., Garbow, Joel R., Hallahan, Andrew N., DeWees, Todd A., Laszlo, Andrei, Hallahan, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741505/
https://www.ncbi.nlm.nih.gov/pubmed/26413814

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