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Anti-α-enolase is a prognostic marker in postoperative lung cancer patients
Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741510/ https://www.ncbi.nlm.nih.gov/pubmed/26551021 |
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author | Hsiao, Kuan-Chung Shih, Neng-Yao Chu, Pei-Yi Hung, Yi-Mei Liao, Jia-Yi Chou, Shao-Wen Yang, Yi-Yuan Chang, Gee-Chen Liu, Ko-Jiunn |
author_facet | Hsiao, Kuan-Chung Shih, Neng-Yao Chu, Pei-Yi Hung, Yi-Mei Liao, Jia-Yi Chou, Shao-Wen Yang, Yi-Yuan Chang, Gee-Chen Liu, Ko-Jiunn |
author_sort | Hsiao, Kuan-Chung |
collection | PubMed |
description | Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of anti-ENO1 Ab were assessed in 85 non-small cell lung carcinoma patients before and after surgery, and were correlated with clinical outcome. After surgery, patients with a higher increase of anti-ENO1 Ab had a lower hazard ratio and a better progression-free survival. Using animal models, we demonstrated that tumor cells reduce the circulating levels of anti-ENO1 Ab through physical absorption and neutralization of anti-ENO1 Ab with surface-expressed and secreted ENO1, respectively. Mice transplanted with ENO1-overexpressing tumors generated ENO1-specific regulatory T cells to suppress the production of anti-ENO1 Ab. Our results suggest that the increase of anti-ENO1 Ab may reflect anti-tumor immune responses and serve as a prognostic marker in postoperative lung cancer patients. |
format | Online Article Text |
id | pubmed-4741510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-47415102016-03-15 Anti-α-enolase is a prognostic marker in postoperative lung cancer patients Hsiao, Kuan-Chung Shih, Neng-Yao Chu, Pei-Yi Hung, Yi-Mei Liao, Jia-Yi Chou, Shao-Wen Yang, Yi-Yuan Chang, Gee-Chen Liu, Ko-Jiunn Oncotarget Clinical Research Paper Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of anti-ENO1 Ab were assessed in 85 non-small cell lung carcinoma patients before and after surgery, and were correlated with clinical outcome. After surgery, patients with a higher increase of anti-ENO1 Ab had a lower hazard ratio and a better progression-free survival. Using animal models, we demonstrated that tumor cells reduce the circulating levels of anti-ENO1 Ab through physical absorption and neutralization of anti-ENO1 Ab with surface-expressed and secreted ENO1, respectively. Mice transplanted with ENO1-overexpressing tumors generated ENO1-specific regulatory T cells to suppress the production of anti-ENO1 Ab. Our results suggest that the increase of anti-ENO1 Ab may reflect anti-tumor immune responses and serve as a prognostic marker in postoperative lung cancer patients. Impact Journals LLC 2015-09-26 /pmc/articles/PMC4741510/ /pubmed/26551021 Text en Copyright: © 2015 Hsiao et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Hsiao, Kuan-Chung Shih, Neng-Yao Chu, Pei-Yi Hung, Yi-Mei Liao, Jia-Yi Chou, Shao-Wen Yang, Yi-Yuan Chang, Gee-Chen Liu, Ko-Jiunn Anti-α-enolase is a prognostic marker in postoperative lung cancer patients |
title | Anti-α-enolase is a prognostic marker in postoperative lung cancer patients |
title_full | Anti-α-enolase is a prognostic marker in postoperative lung cancer patients |
title_fullStr | Anti-α-enolase is a prognostic marker in postoperative lung cancer patients |
title_full_unstemmed | Anti-α-enolase is a prognostic marker in postoperative lung cancer patients |
title_short | Anti-α-enolase is a prognostic marker in postoperative lung cancer patients |
title_sort | anti-α-enolase is a prognostic marker in postoperative lung cancer patients |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741510/ https://www.ncbi.nlm.nih.gov/pubmed/26551021 |
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