Cargando…

Anti-α-enolase is a prognostic marker in postoperative lung cancer patients

Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsiao, Kuan-Chung, Shih, Neng-Yao, Chu, Pei-Yi, Hung, Yi-Mei, Liao, Jia-Yi, Chou, Shao-Wen, Yang, Yi-Yuan, Chang, Gee-Chen, Liu, Ko-Jiunn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741510/
https://www.ncbi.nlm.nih.gov/pubmed/26551021
_version_ 1782414007563452416
author Hsiao, Kuan-Chung
Shih, Neng-Yao
Chu, Pei-Yi
Hung, Yi-Mei
Liao, Jia-Yi
Chou, Shao-Wen
Yang, Yi-Yuan
Chang, Gee-Chen
Liu, Ko-Jiunn
author_facet Hsiao, Kuan-Chung
Shih, Neng-Yao
Chu, Pei-Yi
Hung, Yi-Mei
Liao, Jia-Yi
Chou, Shao-Wen
Yang, Yi-Yuan
Chang, Gee-Chen
Liu, Ko-Jiunn
author_sort Hsiao, Kuan-Chung
collection PubMed
description Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of anti-ENO1 Ab were assessed in 85 non-small cell lung carcinoma patients before and after surgery, and were correlated with clinical outcome. After surgery, patients with a higher increase of anti-ENO1 Ab had a lower hazard ratio and a better progression-free survival. Using animal models, we demonstrated that tumor cells reduce the circulating levels of anti-ENO1 Ab through physical absorption and neutralization of anti-ENO1 Ab with surface-expressed and secreted ENO1, respectively. Mice transplanted with ENO1-overexpressing tumors generated ENO1-specific regulatory T cells to suppress the production of anti-ENO1 Ab. Our results suggest that the increase of anti-ENO1 Ab may reflect anti-tumor immune responses and serve as a prognostic marker in postoperative lung cancer patients.
format Online
Article
Text
id pubmed-4741510
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-47415102016-03-15 Anti-α-enolase is a prognostic marker in postoperative lung cancer patients Hsiao, Kuan-Chung Shih, Neng-Yao Chu, Pei-Yi Hung, Yi-Mei Liao, Jia-Yi Chou, Shao-Wen Yang, Yi-Yuan Chang, Gee-Chen Liu, Ko-Jiunn Oncotarget Clinical Research Paper Our previous studies suggest that antibodies against ENO1 (anti-ENO1 Ab) have a protective role in patients with non-small cell lung carcinoma. In this study, we evaluated the prognostic value of anti-ENO1 Ab levels in non-small cell lung carcinoma patients undergoing surgery. Circulating levels of anti-ENO1 Ab were assessed in 85 non-small cell lung carcinoma patients before and after surgery, and were correlated with clinical outcome. After surgery, patients with a higher increase of anti-ENO1 Ab had a lower hazard ratio and a better progression-free survival. Using animal models, we demonstrated that tumor cells reduce the circulating levels of anti-ENO1 Ab through physical absorption and neutralization of anti-ENO1 Ab with surface-expressed and secreted ENO1, respectively. Mice transplanted with ENO1-overexpressing tumors generated ENO1-specific regulatory T cells to suppress the production of anti-ENO1 Ab. Our results suggest that the increase of anti-ENO1 Ab may reflect anti-tumor immune responses and serve as a prognostic marker in postoperative lung cancer patients. Impact Journals LLC 2015-09-26 /pmc/articles/PMC4741510/ /pubmed/26551021 Text en Copyright: © 2015 Hsiao et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Hsiao, Kuan-Chung
Shih, Neng-Yao
Chu, Pei-Yi
Hung, Yi-Mei
Liao, Jia-Yi
Chou, Shao-Wen
Yang, Yi-Yuan
Chang, Gee-Chen
Liu, Ko-Jiunn
Anti-α-enolase is a prognostic marker in postoperative lung cancer patients
title Anti-α-enolase is a prognostic marker in postoperative lung cancer patients
title_full Anti-α-enolase is a prognostic marker in postoperative lung cancer patients
title_fullStr Anti-α-enolase is a prognostic marker in postoperative lung cancer patients
title_full_unstemmed Anti-α-enolase is a prognostic marker in postoperative lung cancer patients
title_short Anti-α-enolase is a prognostic marker in postoperative lung cancer patients
title_sort anti-α-enolase is a prognostic marker in postoperative lung cancer patients
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741510/
https://www.ncbi.nlm.nih.gov/pubmed/26551021
work_keys_str_mv AT hsiaokuanchung antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients
AT shihnengyao antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients
AT chupeiyi antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients
AT hungyimei antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients
AT liaojiayi antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients
AT choushaowen antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients
AT yangyiyuan antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients
AT changgeechen antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients
AT liukojiunn antiaenolaseisaprognosticmarkerinpostoperativelungcancerpatients