Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility

Cells induced into senescence exhibit a marked increase in the secretion of pro-inflammatory cytokines termed senescence-associated secretory phenotype (SASP). Here we report that SASP from senescent stromal fibroblasts promote spontaneous morphological changes accompanied by an aggressive migratory...

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Detalles Bibliográficos
Autores principales: Aifuwa, Ivie, Giri, Anjil, Longe, Nick, Lee, Sang Hyuk, An, Steven S., Wirtz, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741548/
https://www.ncbi.nlm.nih.gov/pubmed/26483365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741548/
https://www.ncbi.nlm.nih.gov/pubmed/26483365

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