Cargando…
Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny
The heritability of lifespan is 20-30%, but only a few genes associated with longevity have been identified. To explain this discrepancy, the inheritance of epigenetic features, such as DNA methylation, have been proposed to contribute to the heritability of lifespan. We investigated whether parenta...
Autores principales: | Marttila, Saara, Kananen, Laura, Jylhävä, Juulia, Nevalainen, Tapio, Hervonen, Antti, Jylhä, Marja, Hurme, Mikko |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741551/ https://www.ncbi.nlm.nih.gov/pubmed/26436701 |
Ejemplares similares
-
Methylomic predictors demonstrate the role of NF-κB in old-age mortality and are unrelated to the aging-associated epigenetic drift
por: Jylhävä, Juulia, et al.
Publicado: (2016) -
Increased Paternal Age at Conception Is Associated with Transcriptomic Changes Involved in Mitochondrial Function in Elderly Individuals
por: Nevalainen, Tapio, et al.
Publicado: (2016) -
Molecular mechanisms associated with the strength of the anti-CMV response in nonagenarians
por: Marttila, Saara, et al.
Publicado: (2014) -
Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
por: Marttila, Saara, et al.
Publicado: (2015) -
Number of sons contributes to ageing-associated inflammation
por: Marttila, Saara, et al.
Publicado: (2015)