Cargando…

Dclk1(+) small intestinal epithelial tuft cells display the hallmarks of quiescence and self-renewal

To date, no discrete genetic signature has been defined for isolated Dclk1(+) tuft cells within the small intestine. Furthermore, recent reports on the functional significance of Dclk1(+) cells in the small intestine have been inconsistent. These cells have been proposed to be fully differentiated c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chandrakesan, Parthasarathy, May, Randal, Qu, Dongfeng, Weygant, Nathaniel, Taylor, Vivian E., Li, James D., Ali, Naushad, Sureban, Sripathi M., Qante, Michael, Wang, Timothy C., Bronze, Michael S., Houchen, Courtney W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741574/ https://www.ncbi.nlm.nih.gov/pubmed/26362399

Ejemplares similares

Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury
por: Chandrakesan, Parthasarathy, et al.
Publicado: (2016)

Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells
por: Chandrakesan, Parthasarathy, et al.
Publicado: (2017)

Dclk1 facilitates intestinal tumor growth via enhancing pluripotency and epithelial mesenchymal transition
por: Chandrakesan, Parthasarathy, et al.
Publicado: (2014)

Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism
por: Sureban, Sripathi M., et al.
Publicado: (2015)

DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
por: Sureban, Sripathi M., et al.
Publicado: (2013)

Tuft and Cancer Stem Cell Marker DCLK1: A New Target to Enhance Anti-Tumor Immunity in the Tumor Microenvironment
por: Cao, Zhiyun, et al.
Publicado: (2020)

Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases
por: Ali, Naushad, et al.
Publicado: (2015)

Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis
por: Qu, Dongfeng, et al.
Publicado: (2015)

Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1
por: Weygant, Nathaniel, et al.
Publicado: (2014)

DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma
por: Weygant, Nathaniel, et al.
Publicado: (2014)

Dietary Pectin Increases Intestinal Crypt Stem Cell Survival following Radiation Injury
por: Sureban, Sripathi M., et al.
Publicado: (2015)

Regulatory Roles of Dclk1 in Epithelial Mesenchymal Transition and Cancer Stem Cells
por: Chandrakesan, P, et al.
Publicado: (2016)

Fluvastatin Interferes with Hepatitis C Virus Replication via Microtubule Bundling and a Doublecortin-like Kinase-Mediated Mechanism
por: Ali, Naushad, et al.
Publicado: (2013)

Correction: Fluvastatin Interferes with Hepatitis C Virus Replication via Microtubule Bundling and a Doublecortin-like Kinase-Mediated Mechanism
por: Ali, Naushad, et al.
Publicado: (2013)

DCLK1 Regulates Tumor Stemness and Cisplatin Resistance in Non-small Cell Lung Cancer via ABCD-Member-4
por: Panneerselvam, Janani, et al.
Publicado: (2020)

Overexpression of DCLK1-AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer
por: Qu, Dongfeng, et al.
Publicado: (2019)

DCLK1 Monoclonal Antibody-Based CAR-T Cells as a Novel Treatment Strategy against Human Colorectal Cancers
por: Sureban, Sripathi M., et al.
Publicado: (2019)

Cancer Stem Cell Marker DCLK1 Correlates with Tumorigenic Immune Infiltrates in the Colon and Gastric Adenocarcinoma Microenvironments
por: Wu, Xiangyan, et al.
Publicado: (2020)

Doublecortin-Like Kinase 1 Is Elevated Serologically in Pancreatic Ductal Adenocarcinoma and Widely Expressed on Circulating Tumor Cells
por: Qu, Dongfeng, et al.
Publicado: (2015)

Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism
por: Ali, Naushad, et al.
Publicado: (2020)

Elevated doublecortin-like kinase 1 serum levels revert to baseline after therapy in early stage esophageal adenocarcinoma
por: Christman, Emily M., et al.
Publicado: (2019)

Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity
por: Ding, Ling, et al.
Publicado: (2021)

Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism
por: Sureban, Sripathi M, et al.
Publicado: (2011)

Notch signaling drives development of Barrett’s metaplasia from Dclk1-positive epithelial tuft cells in the murine gastric mucosa
por: Kunze, Bettina, et al.
Publicado: (2021)

Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence
por: Cho, Inchul J., et al.
Publicado: (2019)

Bufalin Inhibits Tumorigenesis, Stemness, and Epithelial–Mesenchymal Transition in Colorectal Cancer through a C-Kit/Slug Signaling Axis
por: Ding, Ling, et al.
Publicado: (2022)

Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19
por: Undi, Ram Babu, et al.
Publicado: (2022)

DCLK1 immunoreactivity in colorectal neoplasia
por: Gagliardi, Giuseppe, et al.
Publicado: (2012)

DCLK1 autoinhibition and activation in tumorigenesis
por: Cheng, Linna, et al.
Publicado: (2021)

Analysis of the clinical significance of DCLK1(+) colorectal cancer using novel monoclonal antibodies against DCLK1
por: Dai, Tianqi, et al.
Publicado: (2018)

Journal of Basic and Clinical Pharmacy signs collaboration agreement with Medknow Publications-Wolters Kluwer Health
por: Harsha, Sree, et al.
Publicado: (2012)

Effect of taxol from Pestalotiopsis mangiferae on A549 cells-In vitro study
por: Kathiravan, Govindarajan, et al.
Publicado: (2009)

Editorial: Novel immunotherapies to treat gastrointestinal solid tumor cancers
por: Sureban, Sripathi M., et al.
Publicado: (2022)

Structural Basis of Inhibition of DCLK1 by Ruxolitinib
por: Jang, Dong Man, et al.
Publicado: (2021)

Tufted angioma
por: Rambhia, Kinjal D., et al.
Publicado: (2016)

Tufted angioma
por: da Silva, Camila Mendes, et al.
Publicado: (2017)

A word from Journal of Basic and Clinical Pharmacy editor's desk
por: Sureban, Sripathi M., et al.
Publicado: (2012)

Exit from quiescence displays a memory of cell growth and division
por: Wang, Xia, et al.
Publicado: (2017)

Inflammatory Mediators and Gut Microbial Toxins Drive Colon Tumorigenesis by IL-23 Dependent Mechanism
por: Panneerselvam, Janani, et al.
Publicado: (2021)

Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche
por: Vanegas, Natalia-Del Pilar, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_11l8quhq05u451ifn1tpge7m9v