Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy

Pancreatic ductal adenocarcinoma (PDAC) cells utilize a novel non-canonical pathway of glutamine metabolism that is essential for tumor growth and redox balance. Inhibition of this metabolic pathway in PDAC can potentially synergize with therapies that increase intracellular reactive oxygen species...

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Detalles Bibliográficos
Autores principales: Li, Doudou, Fu, Zhiqiang, Chen, Ruiwan, Zhao, Xiaohui, Zhou, Yu, Zeng, Bing, Yu, Min, Zhou, Quanbo, Lin, Qing, Gao, Wenchao, Ye, Huilin, Zhou, Jiajia, Li, Zhihua, Liu, Yimin, Chen, Rufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741594/
https://www.ncbi.nlm.nih.gov/pubmed/26439804

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