Revealing very small FLT3 ITD mutated clones by ultra-deep sequencing analysis has important clinical implications in AML patients

FLT3 internal tandem duplication (ITD), one of the most frequent mutations in Acute Myeloid Leukemia (AML), is reported to be an unstable marker, as it can evolve from FLT3 ITD- to ITD+ during the disease course. A single-gene sensitive mutational screening approach may be helpful for better clarify...

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Detalles Bibliográficos
Autores principales: Zuffa, Elisa, Franchini, Eugenia, Papayannidis, Cristina, Baldazzi, Carmen, Simonetti, Giorgia, Testoni, Nicoletta, Abbenante, Maria Chiara, Paolini, Stefania, Sartor, Chiara, Parisi, Sarah, Marconi, Giovanni, Cattina, Federica, Bochicchio, Maria Teresa, Venturi, Claudia, Ottaviani, Emanuela, Cavo, Michele, Martinelli, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741605/
https://www.ncbi.nlm.nih.gov/pubmed/26384303

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