CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity

The transcriptional co-activator with PDZ-binding motif (TAZ) is a downstream effector of the Hippo tumor suppressor pathway, which plays important roles in cancer and stem cell biology. Hippo signaling inactivates TAZ through phosphorylation (mainly at S89). In the current study, we define a new la...

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Detalles Bibliográficos
Autores principales: Zhang, Lin, Chen, Xingcheng, Stauffer, Seth, Yang, Shuping, Chen, Yuanhong, Dong, Jixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741614/
https://www.ncbi.nlm.nih.gov/pubmed/26375055

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