Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor

HER2, a well established oncogenic member of EGFR family, is among the most intensely investigated kinase drug targets. In contrast to hotspot mutations of EGFR, few mutations of HER2 locate in activation loop within kinase domain. We previously reported the molecular mechanism underlying hyper kina...

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Detalles Bibliográficos
Autores principales: Hu, Zexi, Hu, Yong, Liu, Xicheng, Xi, Rongwen, Zhang, Aiqun, Liu, Deruo, Xie, Qiang, Chen, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741629/
https://www.ncbi.nlm.nih.gov/pubmed/26375550

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