Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9

Alternative splicing plays a key role in the DNA damage response and in cancer. Ewing Sarcomas (ES) are aggressive tumors caused by different chromosomal translocations that yield in-frame fusion proteins driving transformation. RNA profiling reveals genes differentially regulated by UV light irradi...

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Detalles Bibliográficos
Autores principales: Fidaleo, Marco, Svetoni, Francesca, Volpe, Elisabetta, Miñana, Belén, Caporossi, Daniela, Paronetto, Maria Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741636/
https://www.ncbi.nlm.nih.gov/pubmed/26450900

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