Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2

Sclerostin domain containing protein 1 (SOSTDC1) is down-regulated and acts as a tumor suppressor in some kinds of cancers. However, the expression pattern and biological significance of SOSTDC1 in thyroid cancer are largely unknown. We demonstrated that SOSTDC1 was significantly down-regulated in t...

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Autores principales: Liang, Weiwei, Guan, Hongyu, He, Xiaoying, Ke, Weijian, Xu, Lijuan, Liu, Liehua, Xiao, Haipeng, Li, Yanbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741639/
https://www.ncbi.nlm.nih.gov/pubmed/26378658
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author Liang, Weiwei
Guan, Hongyu
He, Xiaoying
Ke, Weijian
Xu, Lijuan
Liu, Liehua
Xiao, Haipeng
Li, Yanbing
author_facet Liang, Weiwei
Guan, Hongyu
He, Xiaoying
Ke, Weijian
Xu, Lijuan
Liu, Liehua
Xiao, Haipeng
Li, Yanbing
author_sort Liang, Weiwei
collection PubMed
description Sclerostin domain containing protein 1 (SOSTDC1) is down-regulated and acts as a tumor suppressor in some kinds of cancers. However, the expression pattern and biological significance of SOSTDC1 in thyroid cancer are largely unknown. We demonstrated that SOSTDC1 was significantly down-regulated in thyroid cancer. Ectopic over-expression of SOSTDC1 inhibited proliferation and induced G1/S arrest in thyroid cancer cells. Moreover, SOSTDC1 over-expression suppressed the growth of tumor xenografts in nude mice. We also found that elevated SOSTDC1 led to inhibition of cyclin A2 and cyclin E2. Together, our results demonstrate that SOSTDC1 is down-regulated in thyroid cancer and might be a potential therapeutic target in the treatment of thyroid cancer.
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spelling pubmed-47416392016-03-03 Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2 Liang, Weiwei Guan, Hongyu He, Xiaoying Ke, Weijian Xu, Lijuan Liu, Liehua Xiao, Haipeng Li, Yanbing Oncotarget Research Paper Sclerostin domain containing protein 1 (SOSTDC1) is down-regulated and acts as a tumor suppressor in some kinds of cancers. However, the expression pattern and biological significance of SOSTDC1 in thyroid cancer are largely unknown. We demonstrated that SOSTDC1 was significantly down-regulated in thyroid cancer. Ectopic over-expression of SOSTDC1 inhibited proliferation and induced G1/S arrest in thyroid cancer cells. Moreover, SOSTDC1 over-expression suppressed the growth of tumor xenografts in nude mice. We also found that elevated SOSTDC1 led to inhibition of cyclin A2 and cyclin E2. Together, our results demonstrate that SOSTDC1 is down-regulated in thyroid cancer and might be a potential therapeutic target in the treatment of thyroid cancer. Impact Journals LLC 2015-09-10 /pmc/articles/PMC4741639/ /pubmed/26378658 Text en Copyright: © 2015 Liang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liang, Weiwei
Guan, Hongyu
He, Xiaoying
Ke, Weijian
Xu, Lijuan
Liu, Liehua
Xiao, Haipeng
Li, Yanbing
Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2
title Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2
title_full Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2
title_fullStr Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2
title_full_unstemmed Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2
title_short Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2
title_sort down-regulation of sostdc1 promotes thyroid cancer cell proliferation via regulating cyclin a2 and cyclin e2
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741639/
https://www.ncbi.nlm.nih.gov/pubmed/26378658
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