The complex metabolic network gearing the G(1)/S transition in leukemic stem cells: Hints to a rational use of antineoplastic agents

We defined the stem cell profile of K562 line, demonstrating the expression of the Embryonic Transcription Factors Oct3/4, Sox2, Klf4 and Nanog. This profile was associated with a high vulnerability to the physiological oxidizable substrate pyruvate. remarkably, this substrate was shown to be innocu...

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Detalles Bibliográficos
Autores principales: Stivarou, Theodora, Cipolleschi, Maria Grazia, D'Amico, Massimo, Mannini, Antonella, Mini, Enrico, Rovida, Elisabetta, Dello Sbarba, Persio, Olivotto, Massimo, Marzi, Ilaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741654/
https://www.ncbi.nlm.nih.gov/pubmed/26396171

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