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PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth

Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis. It is evident from growing reports that PI3K/Akt/mTOR and Sonic Hedgehog (Shh) signaling pathways are aberrantly reactivated in pancreatic CSCs. Here, we examined the efficacy of combining NVP-LDE-225 (PI3K/...

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Detalles Bibliográficos
Autores principales:	Sharma, Narinder, Nanta, Rajesh, Sharma, Jay, Gunewardena, Sumedha, Singh, Karan P., Shankar, Sharmila, Srivastava, Rakesh K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741658/ https://www.ncbi.nlm.nih.gov/pubmed/26451606

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