Antigen spreading-induced CD8(+)T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells

A key focus in cancer immunotherapy is to investigate the mechanism of efficacious vaccine responses. Using HIV-1 GAG-p24 in a model PD1-based DNA vaccine, we recently reported that vaccine-elicited CD8(+) T cells conferred complete prevention and therapeutic cure of AB1-GAG malignant mesothelioma i...

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Detalles Bibliográficos
Autores principales: Yu, Zhe, Tan, Zhiwu, Lee, Boon Kiat, Tang, Jiansong, Wu, Xilin, Cheung, Ka-Wai, Lok Lo, Nathan Tin, Man, Kwan, Liu, Li, Chen, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741703/
https://www.ncbi.nlm.nih.gov/pubmed/26431275

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