A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL

B-cell chronic lymphocytic leukemia (CLL) is characterized by differential BCR signaling and autoimmune complications. Complement modulates B-cell function via C3d and CD21 cross-linked to the B-cell receptor (BCR). We hypothesized that CD21 contributes to BCR signaling and participates in the autoi...

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Detalles Bibliográficos
Autores principales: Nichols, Eva-Maria, Jones, Rachel, Watson, Rachael, Pepper, Chris J., Fegan, Chris, Marchbank, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741721/
https://www.ncbi.nlm.nih.gov/pubmed/26452134

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