PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss

The role of PDGF-B and its receptor in meningeal tumorigenesis is not clear. We investigated the role of PDGF-B in mouse meningioma development by generating autocrine stimulation of the arachnoid through the platelet-derived growth factor receptor (PDGFR) using the RCAStv-a system. To specifically...

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Detalles Bibliográficos
Autores principales: Peyre, Matthieu, Salaud, Céline, Clermont-Taranchon, Estelle, Niwa-Kawakita, Michiko, Goutagny, Stephane, Mawrin, Christian, Giovannini, Marco, Kalamarides, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741724/
https://www.ncbi.nlm.nih.gov/pubmed/26418719

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