Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression

Deficiency of tumor suppressor FLCN leads to the activation of the mTOR signaling pathway in human BHD-associated renal cell carcinomas (RCC). We have previously developed a renal distal tubule-collecting duct-Henle's loop-specific Flcn knockout (KO) mouse model (Flcn(flox/flox)/Ksp-Cre). This...

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Detalles Bibliográficos
Autores principales: Wu, Mingsong, Si, Shuhui, Li, Yan, Schoen, Susan, Xiao, Guang-Qian, Li, Xueying, Teh, Bin Tean, Wu, Guan, Chen, Jindong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741728/
https://www.ncbi.nlm.nih.gov/pubmed/26418749

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