Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma

Glioblastoma (GBM) is an aggressive malignancy associated with profound host immunosuppression. Microglia and macrophages infiltrating GBM acquire the pro-tumorigenic, M2 phenotype and support tumor invasion, proliferation, survival, angiogenesis and block immune responses both locally and systemati...

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Detalles Bibliográficos
Autores principales: Mieczkowski, Jakub, Kocyk, Marta, Nauman, Pawel, Gabrusiewicz, Konrad, Sielska, Małgorzata, Przanowski, Piotr, Maleszewska, Marta, Rajan, Wenson D., Pszczolkowska, Dominika, Tykocki, Tomasz, Grajkowska, Wieslawa, Kotulska, Katarzyna, Roszkowski, Marcin, Kostkiewicz, Boguslaw, Kaminska, Bozena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741750/
https://www.ncbi.nlm.nih.gov/pubmed/26427514

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