Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden

The membrane-anchored serine proteases are a unique group of trypsin-like serine proteases that are tethered to the cell surface via transmembrane domains or glycosyl-phosphatidylinositol-anchors. Overexpressed in tumors, with pro-tumorigenic properties, they are attractive targets for protease-acti...

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Detalles Bibliográficos
Autores principales: Martin, Erik W., Buzza, Marguerite S., Driesbaugh, Kathryn H., Liu, Shihui, Fortenberry, Yolanda M., Leppla, Stephen H., Antalis, Toni M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741784/
https://www.ncbi.nlm.nih.gov/pubmed/26392335

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