Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation

Cancer cells robustly expel lactate produced through enhanced glycolysis via monocarboxylate transporters (MCTs) and maintain alkaline intracellular pH. To develop a novel therapeutic strategy against multiple myeloma (MM), which still remains incurable, we explored the impact of perturbing a metabo...

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Detalles Bibliográficos
Autores principales: Hanson, Derek James, Nakamura, Shingen, Amachi, Ryota, Hiasa, Masahiro, Oda, Asuka, Tsuji, Daisuke, Itoh, Kohji, Harada, Takeshi, Horikawa, Kazuki, Teramachi, Jumpei, Miki, Hirokazu, Matsumoto, Toshio, Abe, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741786/
https://www.ncbi.nlm.nih.gov/pubmed/26384349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741786/
https://www.ncbi.nlm.nih.gov/pubmed/26384349

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