Cargando…
The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
Patients with pathological complete remission (pCR) after treated with neoadjuvant chemoradiotherapy (nCRT) have better long-term outcome and may receive conservative treatments in locally advanced rectal cancer (LARC). The study aimed to evaluate the value of forceps biopsy and core needle biopsy i...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741812/ https://www.ncbi.nlm.nih.gov/pubmed/26416245 |
_version_ | 1782414075811069952 |
---|---|
author | Tang, Jing-Hua An, Xin Lin, Xi Gao, Yuan-Hong Liu, Guo-Chen Kong, Ling-Heng Pan, Zhi-Zhong Ding, Pei-Rong |
author_facet | Tang, Jing-Hua An, Xin Lin, Xi Gao, Yuan-Hong Liu, Guo-Chen Kong, Ling-Heng Pan, Zhi-Zhong Ding, Pei-Rong |
author_sort | Tang, Jing-Hua |
collection | PubMed |
description | Patients with pathological complete remission (pCR) after treated with neoadjuvant chemoradiotherapy (nCRT) have better long-term outcome and may receive conservative treatments in locally advanced rectal cancer (LARC). The study aimed to evaluate the value of forceps biopsy and core needle biopsy in prediction of pCR in LARC treated with nCRT. In total, 120patients entered this study. Sixty-one consecutive patients received preoperative forceps biopsy during endoscopic examination. Ex vivo core needle biopsy was performed in resected specimens of another 43 consecutive patients. The accuracy for ex vivo core needle biopsy was significantly higher than forceps biopsy (76.7% vs. 36.1%; p < 0.001). The sensitivity for ex vivo core needle biopsy was significantly lower in good responder (TRG 3) than poor responder (TRG ≤ 2) (52.9% vs. 94.1%; p = 0.017). In vivo core needle biopsy was further performed in 16 patients with good response. Eleven patients had residual cancer cells in final resected specimens, among whom 4 (36.4%) patients were biopsy positive. In conclusion, routine forceps biopsy was of limited value in identifying pCR after nCRT. Although core needle biopsy might further identify a subset of patients with residual cancer cells, the accuracy was not substantially increased in good responders. |
format | Online Article Text |
id | pubmed-4741812 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-47418122016-03-11 The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy Tang, Jing-Hua An, Xin Lin, Xi Gao, Yuan-Hong Liu, Guo-Chen Kong, Ling-Heng Pan, Zhi-Zhong Ding, Pei-Rong Oncotarget Clinical Research Paper Patients with pathological complete remission (pCR) after treated with neoadjuvant chemoradiotherapy (nCRT) have better long-term outcome and may receive conservative treatments in locally advanced rectal cancer (LARC). The study aimed to evaluate the value of forceps biopsy and core needle biopsy in prediction of pCR in LARC treated with nCRT. In total, 120patients entered this study. Sixty-one consecutive patients received preoperative forceps biopsy during endoscopic examination. Ex vivo core needle biopsy was performed in resected specimens of another 43 consecutive patients. The accuracy for ex vivo core needle biopsy was significantly higher than forceps biopsy (76.7% vs. 36.1%; p < 0.001). The sensitivity for ex vivo core needle biopsy was significantly lower in good responder (TRG 3) than poor responder (TRG ≤ 2) (52.9% vs. 94.1%; p = 0.017). In vivo core needle biopsy was further performed in 16 patients with good response. Eleven patients had residual cancer cells in final resected specimens, among whom 4 (36.4%) patients were biopsy positive. In conclusion, routine forceps biopsy was of limited value in identifying pCR after nCRT. Although core needle biopsy might further identify a subset of patients with residual cancer cells, the accuracy was not substantially increased in good responders. Impact Journals LLC 2015-09-18 /pmc/articles/PMC4741812/ /pubmed/26416245 Text en Copyright: © 2015 Tang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Tang, Jing-Hua An, Xin Lin, Xi Gao, Yuan-Hong Liu, Guo-Chen Kong, Ling-Heng Pan, Zhi-Zhong Ding, Pei-Rong The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy |
title | The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy |
title_full | The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy |
title_fullStr | The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy |
title_full_unstemmed | The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy |
title_short | The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy |
title_sort | value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741812/ https://www.ncbi.nlm.nih.gov/pubmed/26416245 |
work_keys_str_mv | AT tangjinghua thevalueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT anxin thevalueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT linxi thevalueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT gaoyuanhong thevalueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT liuguochen thevalueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT konglingheng thevalueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT panzhizhong thevalueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT dingpeirong thevalueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT tangjinghua valueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT anxin valueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT linxi valueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT gaoyuanhong valueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT liuguochen valueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT konglingheng valueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT panzhizhong valueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy AT dingpeirong valueofforcepsbiopsyandcoreneedlebiopsyinpredictionofpathologiccompleteremissioninlocallyadvancedrectalcancertreatedwithneoadjuvantchemoradiotherapy |