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High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer

BACKGROUND: To investigate the role of PD-L1 expression in tumor recurrence and metastasis in Chinese patients with breast cancer. METHODS: Suitable tissue samples were available from 870 patients with breast cancer. Paraffin-embedded tumor sections were stained with PD-L1 antibody. The correlations...

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Autores principales: Qin, Tao, Zeng, Yin-duo, Qin, Ge, Xu, Fei, Lu, Jia-bin, Fang, Wen-feng, Xue, Cong, Zhan, Jian-hua, Zhang, Xin-ke, Zheng, Qiu-fan, Peng, Rou-jun, Yuan, Zhong-yu, Zhang, Li, Wang, Shu-sen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741818/
https://www.ncbi.nlm.nih.gov/pubmed/26378017
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author Qin, Tao
Zeng, Yin-duo
Qin, Ge
Xu, Fei
Lu, Jia-bin
Fang, Wen-feng
Xue, Cong
Zhan, Jian-hua
Zhang, Xin-ke
Zheng, Qiu-fan
Peng, Rou-jun
Yuan, Zhong-yu
Zhang, Li
Wang, Shu-sen
author_facet Qin, Tao
Zeng, Yin-duo
Qin, Ge
Xu, Fei
Lu, Jia-bin
Fang, Wen-feng
Xue, Cong
Zhan, Jian-hua
Zhang, Xin-ke
Zheng, Qiu-fan
Peng, Rou-jun
Yuan, Zhong-yu
Zhang, Li
Wang, Shu-sen
author_sort Qin, Tao
collection PubMed
description BACKGROUND: To investigate the role of PD-L1 expression in tumor recurrence and metastasis in Chinese patients with breast cancer. METHODS: Suitable tissue samples were available from 870 patients with breast cancer. Paraffin-embedded tumor sections were stained with PD-L1 antibody. The correlations between PD-L1 expression and clinical characteristics, ER/PR/HER2 status and survival parameters were analyzed. Kaplan-Meier and univariate Cox proportional hazards model analyses were used to compare the survival of patients with high PD-L1 expression and patients with no PD-L1 expression. RESULTS: The median follow-up time was 98 months(range, 17–265 months). The positive rate of PD-L1 expression in breast cancer was 21.7% (189/870). PD-L1 high expression was inversely associated with larger tumor size, higher tumor grade, more positive lymph node number, as well as negative ER and PR status. PD-L1 expression was particularly higher in TNBC compared with non-TNBC, although no statistical significance was observed. Nomogram logistic regression results based on clinical and pathological features showed that the following factors were more likely associated with high PD-L1 expression: patient age younger than 35 years, larger tumor size, lymphovascular invasion and advanced stage. Our data indicated that patients with high PD-L1 expression had poor DFS, DMFS and overall survival compared with those with no PD-L1 expression. Univariate Cox proportional hazards model analysis showed that PD-L1 was an independent prognostic factor for tumor prognosis. CONCLUSIONS: PD-L1 expression is an important indicator of unfavorable prognosis in breast cancer patients.
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spelling pubmed-47418182016-03-11 High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer Qin, Tao Zeng, Yin-duo Qin, Ge Xu, Fei Lu, Jia-bin Fang, Wen-feng Xue, Cong Zhan, Jian-hua Zhang, Xin-ke Zheng, Qiu-fan Peng, Rou-jun Yuan, Zhong-yu Zhang, Li Wang, Shu-sen Oncotarget Clinical Research Paper BACKGROUND: To investigate the role of PD-L1 expression in tumor recurrence and metastasis in Chinese patients with breast cancer. METHODS: Suitable tissue samples were available from 870 patients with breast cancer. Paraffin-embedded tumor sections were stained with PD-L1 antibody. The correlations between PD-L1 expression and clinical characteristics, ER/PR/HER2 status and survival parameters were analyzed. Kaplan-Meier and univariate Cox proportional hazards model analyses were used to compare the survival of patients with high PD-L1 expression and patients with no PD-L1 expression. RESULTS: The median follow-up time was 98 months(range, 17–265 months). The positive rate of PD-L1 expression in breast cancer was 21.7% (189/870). PD-L1 high expression was inversely associated with larger tumor size, higher tumor grade, more positive lymph node number, as well as negative ER and PR status. PD-L1 expression was particularly higher in TNBC compared with non-TNBC, although no statistical significance was observed. Nomogram logistic regression results based on clinical and pathological features showed that the following factors were more likely associated with high PD-L1 expression: patient age younger than 35 years, larger tumor size, lymphovascular invasion and advanced stage. Our data indicated that patients with high PD-L1 expression had poor DFS, DMFS and overall survival compared with those with no PD-L1 expression. Univariate Cox proportional hazards model analysis showed that PD-L1 was an independent prognostic factor for tumor prognosis. CONCLUSIONS: PD-L1 expression is an important indicator of unfavorable prognosis in breast cancer patients. Impact Journals LLC 2015-09-10 /pmc/articles/PMC4741818/ /pubmed/26378017 Text en Copyright: © 2015 Qin et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Clinical Research Paper
Qin, Tao
Zeng, Yin-duo
Qin, Ge
Xu, Fei
Lu, Jia-bin
Fang, Wen-feng
Xue, Cong
Zhan, Jian-hua
Zhang, Xin-ke
Zheng, Qiu-fan
Peng, Rou-jun
Yuan, Zhong-yu
Zhang, Li
Wang, Shu-sen
High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
title High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
title_full High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
title_fullStr High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
title_full_unstemmed High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
title_short High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
title_sort high pd-l1 expression was associated with poor prognosis in 870 chinese patients with breast cancer
topic Clinical Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741818/
https://www.ncbi.nlm.nih.gov/pubmed/26378017
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