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High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer
BACKGROUND: To investigate the role of PD-L1 expression in tumor recurrence and metastasis in Chinese patients with breast cancer. METHODS: Suitable tissue samples were available from 870 patients with breast cancer. Paraffin-embedded tumor sections were stained with PD-L1 antibody. The correlations...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741818/ https://www.ncbi.nlm.nih.gov/pubmed/26378017 |
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author | Qin, Tao Zeng, Yin-duo Qin, Ge Xu, Fei Lu, Jia-bin Fang, Wen-feng Xue, Cong Zhan, Jian-hua Zhang, Xin-ke Zheng, Qiu-fan Peng, Rou-jun Yuan, Zhong-yu Zhang, Li Wang, Shu-sen |
author_facet | Qin, Tao Zeng, Yin-duo Qin, Ge Xu, Fei Lu, Jia-bin Fang, Wen-feng Xue, Cong Zhan, Jian-hua Zhang, Xin-ke Zheng, Qiu-fan Peng, Rou-jun Yuan, Zhong-yu Zhang, Li Wang, Shu-sen |
author_sort | Qin, Tao |
collection | PubMed |
description | BACKGROUND: To investigate the role of PD-L1 expression in tumor recurrence and metastasis in Chinese patients with breast cancer. METHODS: Suitable tissue samples were available from 870 patients with breast cancer. Paraffin-embedded tumor sections were stained with PD-L1 antibody. The correlations between PD-L1 expression and clinical characteristics, ER/PR/HER2 status and survival parameters were analyzed. Kaplan-Meier and univariate Cox proportional hazards model analyses were used to compare the survival of patients with high PD-L1 expression and patients with no PD-L1 expression. RESULTS: The median follow-up time was 98 months(range, 17–265 months). The positive rate of PD-L1 expression in breast cancer was 21.7% (189/870). PD-L1 high expression was inversely associated with larger tumor size, higher tumor grade, more positive lymph node number, as well as negative ER and PR status. PD-L1 expression was particularly higher in TNBC compared with non-TNBC, although no statistical significance was observed. Nomogram logistic regression results based on clinical and pathological features showed that the following factors were more likely associated with high PD-L1 expression: patient age younger than 35 years, larger tumor size, lymphovascular invasion and advanced stage. Our data indicated that patients with high PD-L1 expression had poor DFS, DMFS and overall survival compared with those with no PD-L1 expression. Univariate Cox proportional hazards model analysis showed that PD-L1 was an independent prognostic factor for tumor prognosis. CONCLUSIONS: PD-L1 expression is an important indicator of unfavorable prognosis in breast cancer patients. |
format | Online Article Text |
id | pubmed-4741818 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-47418182016-03-11 High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer Qin, Tao Zeng, Yin-duo Qin, Ge Xu, Fei Lu, Jia-bin Fang, Wen-feng Xue, Cong Zhan, Jian-hua Zhang, Xin-ke Zheng, Qiu-fan Peng, Rou-jun Yuan, Zhong-yu Zhang, Li Wang, Shu-sen Oncotarget Clinical Research Paper BACKGROUND: To investigate the role of PD-L1 expression in tumor recurrence and metastasis in Chinese patients with breast cancer. METHODS: Suitable tissue samples were available from 870 patients with breast cancer. Paraffin-embedded tumor sections were stained with PD-L1 antibody. The correlations between PD-L1 expression and clinical characteristics, ER/PR/HER2 status and survival parameters were analyzed. Kaplan-Meier and univariate Cox proportional hazards model analyses were used to compare the survival of patients with high PD-L1 expression and patients with no PD-L1 expression. RESULTS: The median follow-up time was 98 months(range, 17–265 months). The positive rate of PD-L1 expression in breast cancer was 21.7% (189/870). PD-L1 high expression was inversely associated with larger tumor size, higher tumor grade, more positive lymph node number, as well as negative ER and PR status. PD-L1 expression was particularly higher in TNBC compared with non-TNBC, although no statistical significance was observed. Nomogram logistic regression results based on clinical and pathological features showed that the following factors were more likely associated with high PD-L1 expression: patient age younger than 35 years, larger tumor size, lymphovascular invasion and advanced stage. Our data indicated that patients with high PD-L1 expression had poor DFS, DMFS and overall survival compared with those with no PD-L1 expression. Univariate Cox proportional hazards model analysis showed that PD-L1 was an independent prognostic factor for tumor prognosis. CONCLUSIONS: PD-L1 expression is an important indicator of unfavorable prognosis in breast cancer patients. Impact Journals LLC 2015-09-10 /pmc/articles/PMC4741818/ /pubmed/26378017 Text en Copyright: © 2015 Qin et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Qin, Tao Zeng, Yin-duo Qin, Ge Xu, Fei Lu, Jia-bin Fang, Wen-feng Xue, Cong Zhan, Jian-hua Zhang, Xin-ke Zheng, Qiu-fan Peng, Rou-jun Yuan, Zhong-yu Zhang, Li Wang, Shu-sen High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer |
title | High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer |
title_full | High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer |
title_fullStr | High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer |
title_full_unstemmed | High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer |
title_short | High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer |
title_sort | high pd-l1 expression was associated with poor prognosis in 870 chinese patients with breast cancer |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741818/ https://www.ncbi.nlm.nih.gov/pubmed/26378017 |
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