Cargando…

Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells

A sharp definition of what a senescent cell is still lacking since we do not have in depth understanding of mechanisms that induce cellular senescence. In addition, senescent cells are heterogeneous, in that not all of them express the same genes and present the same phenotype. To further clarify th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Capasso, Stefania, Alessio, Nicola, Squillaro, Tiziana, Di Bernardo, Giovanni, Melone, Mariarosa A., Cipollaro, Marilena, Peluso, Gianfranco, Galderisi, Umberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741838/ https://www.ncbi.nlm.nih.gov/pubmed/26540573

Ejemplares similares

Senescence Phenomena and Metabolic Alteration in Mesenchymal Stromal Cells from a Mouse Model of Rett Syndrome
por: Squillaro, Tiziana, et al.
Publicado: (2019)

Neural stem cells from a mouse model of Rett syndrome are prone to senescence, show reduced capacity to cope with genotoxic stress, and are impaired in the differentiation process
por: Alessio, Nicola, et al.
Publicado: (2018)

Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity
por: Özcan, Servet, et al.
Publicado: (2015)

Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process
por: Alessio, Nicola, et al.
Publicado: (2014)

The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells
por: Alessio, Nicola, et al.
Publicado: (2019)

Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: new perspective for Rett syndrome
por: Squillaro, Tiziana, et al.
Publicado: (2012)

Stress and stem cells: adult Muse cells tolerate extensive genotoxic stimuli better than mesenchymal stromal cells
por: Alessio, Nicola, et al.
Publicado: (2018)

Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence
por: Alessio, Nicola, et al.
Publicado: (2020)

Correction: Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence
por: Alessio, Nicola, et al.
Publicado: (2022)

Circulating factors present in the sera of naturally skinny people may influence cell commitment and adipocyte differentiation of mesenchymal stromal cells
por: Alessio, Nicola, et al.
Publicado: (2019)

Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence()()()
por: Alessio, Nicola, et al.
Publicado: (2017)

Biomolecular Evaluation of Piceatannol’s Effects in Counteracting the Senescence of Mesenchymal Stromal Cells: A New Candidate for Senotherapeutics?
por: Alessio, Nicola, et al.
Publicado: (2021)

Sera of overweight people promote in vitro adipocyte differentiation of bone marrow stromal cells
por: Di Bernardo, Giovanni, et al.
Publicado: (2014)

Hybrid complexes of high and low molecular weight hyaluronan delay in vitro replicative senescence of mesenchymal stromal cells: a pilot study for future therapeutic application
por: Alessio, Nicola, et al.
Publicado: (2018)

Obesity is associated with senescence of mesenchymal stromal cells derived from bone marrow, subcutaneous and visceral fat of young mice
por: Alessio, Nicola, et al.
Publicado: (2020)

Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti‐tumour properties
por: Alessio, Nicola, et al.
Publicado: (2023)

Ginsenoside Rg3 inhibits the senescence of prostate stromal cells through down-regulation of interleukin 8 expression
por: Peng, Yanfei, et al.
Publicado: (2017)

MiR-23a-depressed autophagy is a participant in PUVA- and UVB-induced premature senescence
por: Zhang, Jia-an, et al.
Publicado: (2016)

Autophagy through 4EBP1 and AMPK regulates oxidative stress-induced premature senescence in auditory cells
por: Tsuchihashi, Nana Akagi, et al.
Publicado: (2014)

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
por: Olivieri, Fabiola, et al.
Publicado: (2015)

MUSE Stem Cells Can Be Isolated from Stromal Compartment of Mouse Bone Marrow, Adipose Tissue, and Ear Connective Tissue: A Comparative Study of Their In Vitro Properties
por: Aprile, Domenico, et al.
Publicado: (2021)

Long non-coding RNAs in regulation of adipogenesis and adipose tissue function
por: Squillaro, Tiziana, et al.
Publicado: (2020)

Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway
por: Su, Fengtao, et al.
Publicado: (2015)

Role of glycosphingolipid SSEA‐3 and FGF2 in the stemness and lineage commitment of multilineage differentiating stress enduring (MUSE) cells
por: Aprile, Domenico, et al.
Publicado: (2022)

Epigenetic clock analyses of cellular senescence and ageing
por: Lowe, Donna, et al.
Publicado: (2016)

MeCP2 mediated dysfunction in senescent EPCs
por: Wang, Chunli, et al.
Publicado: (2017)

Run-on of germline apoptosis promotes gonad senescence in C. elegans
por: de la Guardia, Yila, et al.
Publicado: (2016)

Micro-RNAs: Crossroads between the Exposure to Environmental Particulate Pollution and the Obstructive Pulmonary Disease
por: Finicelli, Mauro, et al.
Publicado: (2020)

Polyphenols, the Healthy Brand of Olive Oil: Insights and Perspectives
por: Finicelli, Mauro, et al.
Publicado: (2021)

RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
por: Cai, Xiaoyu, et al.
Publicado: (2016)

Gadd45b deficiency promotes premature senescence and skin aging
por: Magimaidas, Andrew, et al.
Publicado: (2016)

Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation
por: Xie, Jun, et al.
Publicado: (2017)

Senoptosis: non-lethal DNA cleavage as a route to deep senescence
por: Studencka, Maja, et al.
Publicado: (2017)

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight
por: Rigacci, Stefania, et al.
Publicado: (2015)

NOX4 downregulation leads to senescence of human vascular smooth muscle cells
por: Przybylska, Dorota, et al.
Publicado: (2016)

Drug-induced premature senescence model in human dental follicle stem cells
por: Zhai, Yuanfen, et al.
Publicado: (2016)

ATF6α regulates morphological changes associated with senescence in human fibroblasts
por: Druelle, Clémentine, et al.
Publicado: (2016)

Aging with ING: a comparative study of different forms of stress induced premature senescence
por: Rajarajacholan, Uma Karthika, et al.
Publicado: (2015)

Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature
por: Grabowska, Wioleta, et al.
Publicado: (2016)

BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21
por: Lee, Hyemin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_q2v63vg8sof7t1iqs8igpqofj0