Mutant AKT1-E17K is oncogenic in lung epithelial cells

The hotspot E17K mutation in the pleckstrin homology domain of AKT1 occurs in approximately 0.6–2% of human lung cancers. In this manuscript, we sought to determine whether this AKT1 variant is a bona-fide activating mutation and plays a role in the development of lung cancer. Here we report that in...

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Detalles Bibliográficos
Autores principales: De Marco, Carmela, Malanga, Donatella, Rinaldo, Nicola, De Vita, Fernanda, Scrima, Marianna, Lovisa, Sara, Fabris, Linda, Carriero, Maria Vincenza, Franco, Renato, Rizzuto, Antonia, Baldassarre, Gustavo, Viglietto, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741851/
https://www.ncbi.nlm.nih.gov/pubmed/26053093

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