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Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

Nitroxoline is an antibiotic by chelating Zn(2+) and Fe(2+) from biofilm matrix. In this study, nitroxoline induced G1 arrest of cell cycle and subsequent apoptosis in prostate cancer cells through ion chelating-independent pathway. It decreased protein levels of cyclin D1, Cdc25A and phosphorylated...

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Detalles Bibliográficos
Autores principales:	Chang, Wei-Ling, Hsu, Lih-Ching, Leu, Wohn-Jenn, Chen, Ching-Shih, Guh, Jih-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741862/ https://www.ncbi.nlm.nih.gov/pubmed/26447757

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