Cargando…

The 5′-untranslated region of p16(INK4a) melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

CDKN2A/p16(INK4a) is an essential tumor suppressor gene that controls cell cycle progression and replicative senescence. It is also the main melanoma susceptibility gene. Here we report that p16(INK4a) 5′UTR mRNA acts as a cellular Internal Ribosome Entry Site (IRES). The potential for p16(INK4a) 5′...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bisio, Alessandra, Latorre, Elisa, Andreotti, Virginia, Bressac-de Paillerets, Brigitte, Harland, Mark, Scarra, Giovanna Bianchi, Ghiorzo, Paola, Spitale, Robert C., Provenzani, Alessandro, Inga, Alberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741874/ https://www.ncbi.nlm.nih.gov/pubmed/26498684

Ejemplares similares

Functional analysis of a CDKN2A 5’UTR germline variant associated with pancreatic cancer development
por: Bruno, William, et al.
Publicado: (2017)

Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16(INK4A), P14(ARF) or cdk4 genes
por: Soufir, N, et al.
Publicado: (2000)

Melanoma Risk and Melanocyte Biology
por: BERTRAND, Juliette U., et al.
Publicado: (2020)

Heterogeneity and frequency of BRAF mutations in primary melanoma: Comparison between molecular methods and immunohistochemistry
por: Bruno, William, et al.
Publicado: (2016)

The Pleiotropic Effects of YBX1 on HTLV-1 Transcription
por: Smith, Susan, et al.
Publicado: (2023)

Mutation testing in melanoma families: INK4A, CDK4 and INK4D
por: Newton Bishop, J A, et al.
Publicado: (1999)

YBX-1 mediated sorting of miR-133 into hypoxia/reoxygenation-induced EPC-derived exosomes to increase fibroblast angiogenesis and MEndoT
por: Lin, Fengxia, et al.
Publicado: (2019)

The Functional Role of the 3′ Untranslated Region and Poly(A) Tail of Duck Hepatitis A Virus Type 1 in Viral Replication and Regulation of IRES-Mediated Translation
por: Chen, Jun-Hao, et al.
Publicado: (2018)

Transcriptional and post-transcriptional control of autophagy and adipogenesis by YBX1
por: Wu, Ruifan, et al.
Publicado: (2023)

Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes
por: Zhao, Qingwen, et al.
Publicado: (2023)

YBX1 as an oncogenic factor in T-cell acute lymphoblastic leukemia
por: Li, Huan, et al.
Publicado: (2023)

Methylation of the Suppressor Gene p16INK4a: Mechanism and Consequences
por: Tramontano, Alfonso, et al.
Publicado: (2020)

IRES-Mediated Protein Translation Overcomes Suppression by the p14ARF Tumor Suppressor Protein
por: Xi, Song, et al.
Publicado: (2017)

The effects of transferring tumor suppressor gene p16(INK4A) to p16(INK4A)-deleted cancer cells*
por: Lee, Kye Young, et al.
Publicado: (1999)

The ELAV RNA-stability factor HuR binds the 5′-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation
por: Meng, Zheng, et al.
Publicado: (2005)

YBX1 Is a Modulator of MIA/CD-RAP-Dependent Chondrogenesis
por: Schmid, Rainer, et al.
Publicado: (2013)

Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
por: Wiedemeyer, Ruprecht, et al.
Publicado: (2008)

The p16(INK4A) tumor suppressor regulates cellular oxidative stress
por: Jenkins, Noah C., et al.
Publicado: (2010)

The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs
por: Zhang, Kezhong, et al.
Publicado: (2020)

Untranslated regions of mRNAs
por: Mignone, Flavio, et al.
Publicado: (2002)

HIF1α-dependent hypoxia response in myeloid cells requires IRE1α
por: Mawambo, Gaëlle, et al.
Publicado: (2023)

Alterations of tumor suppressor gene p16(INK4a )in pancreatic ductal carcinoma
por: Attri, Jyotika, et al.
Publicado: (2005)

INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors
por: Li, Qing, et al.
Publicado: (2022)

Uncoupling of EGFR–RAS signaling and nuclear localization of YBX1 in colorectal cancer
por: Roßner, F, et al.
Publicado: (2016)

Satellite RNAs promote pancreatic oncogenic processes via the dysfunction of YBX1
por: Kishikawa, Takahiro, et al.
Publicado: (2016)

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes
por: Shurtleff, Matthew J., et al.
Publicado: (2017)

YBX1 promotes tumor growth by elevating glycolysis in human bladder cancer
por: Xu, Liuyu, et al.
Publicado: (2017)

Long noncoding RNAs implicated in embryonic development in Ybx1 knockout zebrafish
por: Huang, Chen, et al.
Publicado: (2021)

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates
por: Liu, Xiao-Man, et al.
Publicado: (2021)

YBX1 mediates translation of oncogenic transcripts to control cell competition in AML
por: Perner, Florian, et al.
Publicado: (2021)

LncRNA USP2-AS1 Promotes Hepatocellular Carcinoma Growth by Enhancing YBX1-Mediated HIF1α Protein Translation Under Hypoxia
por: Chen, Shi-Ping, et al.
Publicado: (2022)

The ODC 3′-Untranslated Region and 5′-Untranslated Region Contain cis-Regulatory Elements: Implications for Carcinogenesis
por: Nowotarski, Shannon L., et al.
Publicado: (2017)

Search for germline alterations in CDKN2A/ARF and CDK4 of 42 Jewish melanoma families with or without neural system tumours
por: Marian, C, et al.
Publicado: (2005)

Properties of untranslated regions of the S. cerevisiae genome
por: Tuller, Tamir, et al.
Publicado: (2009)

Variation in the Untranslated Genome and Susceptibility to Infections
por: Ramsuran, Veron, et al.
Publicado: (2018)

The 5′-Untranslated Region of Picornaviral Genomes
por: Agol, Vadim I.
Publicado: (1991)

The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia
por: Schepens, Bert, et al.
Publicado: (2005)

Hypoxia increases RCC stem cell phenotype via altering the androgen receptor (AR)-lncTCFL5-2-YBX1-SOX2 signaling axis
por: Guo, Changcheng, et al.
Publicado: (2022)

Several Distinct Polycomb Complexes Regulate and Co-Localize on the INK4a Tumor Suppressor Locus
por: Maertens, Goedele N., et al.
Publicado: (2009)

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
por: Maertens, Goedele N, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_0bkqp2don930tr7o94t3q9p8t6