A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

DNA-damaging drugs induce a plethora of molecular and cellular alterations in tumor cells, but their interrelationship is largely obscure. Here, we show that carboplatin treatment of human ovarian carcinoma SKOV3 cells triggers an ordered sequence of events, which precedes the emergence of mitotic c...

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Detalles Bibliográficos
Autores principales: Rohnalter, Verena, Roth, Katrin, Finkernagel, Florian, Adhikary, Till, Obert, Julia, Dorzweiler, Kristina, Bensberg, Maike, Müller-Brüsselbach, Sabine, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741876/
https://www.ncbi.nlm.nih.gov/pubmed/26503466

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