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Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells
The pyruvate dehydrogenase complex (PDHC) and its phosphorylation are considered essential for oncotransformation, but it is unclear whether cancer cells require PDHC to be functional or silenced. We used specific inhibition of PDHC by synthetic structural analogs of pyruvate to resolve this questio...
Autores principales: | Bunik, Victoria I., Artiukhov, Artem, Kazantsev, Alexey, Goncalves, Renata, Daloso, Danilo, Oppermann, Henry, Kulakovskaya, Elena, Lukashev, Nikolay, Fernie, Alisdair, Brand, Martin, Gaunitz, Frank |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741878/ https://www.ncbi.nlm.nih.gov/pubmed/26503465 |
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