Caveolin-1, a stress-related oncotarget, in drug resistance

Caveolin-1 (Cav-1) is both a tumor suppressor and an oncoprotein. Cav-1 overexpression was frequently confirmed in advanced cancer stages and positively associated with ABC transporters, cancer stem cell populations, aerobic glycolysis activity and autophagy. Cav-1 was tied to various stresses inclu...

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Autores principales: Wang, Zhiyu, Wang, Neng, Liu, Pengxi, Peng, Fu, Tang, Hailin, Chen, Qianjun, Xu, Rui, Dai, Yan, Lin, Yi, Xie, Xiaoming, Peng, Cheng, Situ, Honglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741920/
https://www.ncbi.nlm.nih.gov/pubmed/26431273
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author Wang, Zhiyu
Wang, Neng
Liu, Pengxi
Peng, Fu
Tang, Hailin
Chen, Qianjun
Xu, Rui
Dai, Yan
Lin, Yi
Xie, Xiaoming
Peng, Cheng
Situ, Honglin
author_facet Wang, Zhiyu
Wang, Neng
Liu, Pengxi
Peng, Fu
Tang, Hailin
Chen, Qianjun
Xu, Rui
Dai, Yan
Lin, Yi
Xie, Xiaoming
Peng, Cheng
Situ, Honglin
author_sort Wang, Zhiyu
collection PubMed
description Caveolin-1 (Cav-1) is both a tumor suppressor and an oncoprotein. Cav-1 overexpression was frequently confirmed in advanced cancer stages and positively associated with ABC transporters, cancer stem cell populations, aerobic glycolysis activity and autophagy. Cav-1 was tied to various stresses including radiotherapy, fluid shear and oxidative stresses and ultraviolet exposure, and interacted with stress signals such as AMP-activated protein kinase. Finally, a Cav-1 fluctuation model during cancer development is provided and Cav-1 is suggested to be a stress signal and cytoprotective. Loss of Cav-1 may increase susceptibility to oncogenic events. However, research to explore the underlying molecular network between Cav-1 and stress signals is warranted.
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spelling pubmed-47419202016-03-17 Caveolin-1, a stress-related oncotarget, in drug resistance Wang, Zhiyu Wang, Neng Liu, Pengxi Peng, Fu Tang, Hailin Chen, Qianjun Xu, Rui Dai, Yan Lin, Yi Xie, Xiaoming Peng, Cheng Situ, Honglin Oncotarget Review Caveolin-1 (Cav-1) is both a tumor suppressor and an oncoprotein. Cav-1 overexpression was frequently confirmed in advanced cancer stages and positively associated with ABC transporters, cancer stem cell populations, aerobic glycolysis activity and autophagy. Cav-1 was tied to various stresses including radiotherapy, fluid shear and oxidative stresses and ultraviolet exposure, and interacted with stress signals such as AMP-activated protein kinase. Finally, a Cav-1 fluctuation model during cancer development is provided and Cav-1 is suggested to be a stress signal and cytoprotective. Loss of Cav-1 may increase susceptibility to oncogenic events. However, research to explore the underlying molecular network between Cav-1 and stress signals is warranted. Impact Journals LLC 2015-09-27 /pmc/articles/PMC4741920/ /pubmed/26431273 Text en Copyright: © 2015 Wang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Wang, Zhiyu
Wang, Neng
Liu, Pengxi
Peng, Fu
Tang, Hailin
Chen, Qianjun
Xu, Rui
Dai, Yan
Lin, Yi
Xie, Xiaoming
Peng, Cheng
Situ, Honglin
Caveolin-1, a stress-related oncotarget, in drug resistance
title Caveolin-1, a stress-related oncotarget, in drug resistance
title_full Caveolin-1, a stress-related oncotarget, in drug resistance
title_fullStr Caveolin-1, a stress-related oncotarget, in drug resistance
title_full_unstemmed Caveolin-1, a stress-related oncotarget, in drug resistance
title_short Caveolin-1, a stress-related oncotarget, in drug resistance
title_sort caveolin-1, a stress-related oncotarget, in drug resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741920/
https://www.ncbi.nlm.nih.gov/pubmed/26431273
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