Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736

Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the chromosomal translocation t(11;14) that leads to constitutive expression of cyclin D1, a master regulator of the G1-S phase. Chk1 inhibitors have been recently shown to be strongly effective as single agents in MCL. To...

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Detalles Bibliográficos
Autores principales: Restelli, Valentina, Chilà, Rosaria, Lupi, Monica, Rinaldi, Andrea, Kwee, Ivo, Bertoni, Francesco, Damia, Giovanna, Carrassa, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741926/
https://www.ncbi.nlm.nih.gov/pubmed/26439697

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