Cargando…

Silencing of E2F3 suppresses tumor growth of Her2(+) breast cancer cells by restricting mitosis

The E2F transcriptional activators E2F1, E2F2 and E2F3a regulate many important cellular processes, including DNA replication, apoptosis and centrosome duplication. Previously, we demonstrated that silencing E2F1 or E2F3 suppresses centrosome amplification (CA) and chromosome instability (CIN) in He...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Miyoung, Oprea-Ilies, Gabriela, Saavedra, Harold I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741932/ https://www.ncbi.nlm.nih.gov/pubmed/26512919

Ejemplares similares

The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1
por: Lee, Miyoung, et al.
Publicado: (2017)

Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis and Requires RANBP2
por: Di Cesare, Erica, et al.
Publicado: (2023)

The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis
por: Chapard, Christophe, et al.
Publicado: (2015)

Cdk4 and Nek2 Signal Binucleation and Centrosome Amplification in a Her2+ Breast Cancer Model
por: Harrison Pitner, Mary Kathryn, et al.
Publicado: (2013)

Targeted Therapy and Mechanisms of Drug Resistance in Breast Cancer
por: Kinnel, Briana, et al.
Publicado: (2023)

Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT
por: Zheng, Yan, et al.
Publicado: (2022)

Delphinidin Inhibits HER2 and Erk1/2 Signaling and Suppresses Growth of HER2-Overexpressing and Triple Negative Breast Cancer Cell Lines
por: Ozbay, Tuba, et al.
Publicado: (2011)

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210
Publicado: (1992)

Conserved E2F mediated metastasis in mouse models of breast cancer and HER2 positive patients
por: Rennhack, Jonathan, et al.
Publicado: (2015)

HER2/Neu tumorigenesis and metastasis is regulated by E2F activator transcription factors
por: Andrechek, Eran R.
Publicado: (2013)

Mammalian cell growth dynamics in mitosis
por: Miettinen, Teemu P, et al.
Publicado: (2019)

Geraniol suppresses prostate cancer growth through down‐regulation of E2F8
por: Lee, Sanghoon, et al.
Publicado: (2016)

The Role of Notch Signaling and Leptin-Notch Crosstalk in Pancreatic Cancer
por: Harbuzariu, Adriana, et al.
Publicado: (2018)

The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2− Breast Cancer
por: Oshi, Masanori, et al.
Publicado: (2020)

Endometrial carcinoma with ectopic human chorionic gonadotropin expression
por: Lee, Regina, et al.
Publicado: (2015)

Nano-Based Drug Delivery and Targeting to Overcome Drug Resistance of Ovarian Cancers
por: McFadden, Melayshia, et al.
Publicado: (2021)

R-PTP-κ Inhibits Contact-Dependent Cell Growth by Suppressing E2F Activity
por: Sohn, Hyun Ahm, et al.
Publicado: (2022)

Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells
por: Lee, Mi-Young, et al.
Publicado: (2014)

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
por: Thurlings, I, et al.
Publicado: (2017)

Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer
por: Shi, Wengui, et al.
Publicado: (2021)

SUPPRESSION OF MITOSIS AND MACROMOLECULE SYNTHESIS IN ONION ROOTS BY HEAVY WATER
por: Bal, Arya K., et al.
Publicado: (1964)

Inhibition of HER2-integrin signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression
por: Gupta, Parul, et al.
Publicado: (2014)

E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
por: Dahlet, Thomas, et al.
Publicado: (2021)

The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through the ATM-E2F1 signaling pathway
por: Yang, Yang, et al.
Publicado: (2018)

Pre-Clinical Study of the [(18)F]AlF-Labeled HER2 Affibody for Non-Invasive HER2 Detection in Gastric Cancer
por: Han, Jingya, et al.
Publicado: (2022)

HER2-driven breast cancer suppression by the JNK signaling pathway
por: Itah, Zeynep, et al.
Publicado: (2023)

Raptor is Phosphorylated by cdc2 during Mitosis
por: Gwinn, Dana M., et al.
Publicado: (2010)

ANKRD44 Gene Silencing: A Putative Role in Trastuzumab Resistance in Her2-Like Breast Cancer
por: La Ferla, Marco, et al.
Publicado: (2019)

Epigenetic Silencing of HER2 Expression during Epithelial-Mesenchymal Transition Leads to Trastuzumab Resistance in Breast Cancer
por: Nami, Babak, et al.
Publicado: (2021)

Caffeine overcomes a restriction point associated with DNA replication, but does not accelerate mitosis
Publicado: (1990)

DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation
por: Lemmens, Bennie, et al.
Publicado: (2018)

[(18)F]FBEM-Z(HER2:342)-Affibody molecule—a new molecular tracer for in vivo monitoring of HER2 expression by positron emission tomography
por: Kramer-Marek, Gabriela, et al.
Publicado: (2007)

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer
por: Tekedereli, Ibrahim, et al.
Publicado: (2012)

The kinesin-like protein KLP61F is essential for mitosis in Drosophila
Publicado: (1993)

Retraction: The silencing of long non-coding RNA ANRIL suppresses invasion, and promotes apoptosis of retinoblastoma cells through ATM-E2F1 signaling pathway
Publicado: (2021)

Novel retinoblastoma mutation abrogating the interaction to E2F2/3, but not E2F1, led to selective suppression of thyroid tumors
por: Toki, Hideaki, et al.
Publicado: (2014)

Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer
por: Duffy, Ciara, et al.
Publicado: (2020)

Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy
por: Yamashita, Satoshi, et al.
Publicado: (2020)

Invasive Pulmonary Aspergillosis with Hydropneumothorax in a Patient Taking High-Dose Glucocorticoids
por: Dixit, Devika, et al.
Publicado: (2020)

The interplay of pineal hormones and socioeconomic status leading to colorectal cancer disparity
por: Haynes, Talaijha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7qbqvas529ic3fh60c62rus8g2