Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo

eIF6 is an antiassociation factor that regulates the availability of active 80S. Its activation is driven by the RACK1/PKCβ axis, in a mTORc1 independent manner. We previously described that eIF6 haploinsufficiency causes a striking survival in the Eμ-Myc mouse lymphoma model, with lifespans extende...

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Detalles Bibliográficos
Autores principales: Miluzio, Annarita, Oliveto, Stefania, Pesce, Elisa, Mutti, Luciano, Murer, Bruno, Grosso, Stefano, Ricciardi, Sara, Brina, Daniela, Biffo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741942/
https://www.ncbi.nlm.nih.gov/pubmed/26462016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741942/
https://www.ncbi.nlm.nih.gov/pubmed/26462016

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