Cargando…

Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo

eIF6 is an antiassociation factor that regulates the availability of active 80S. Its activation is driven by the RACK1/PKCβ axis, in a mTORc1 independent manner. We previously described that eIF6 haploinsufficiency causes a striking survival in the Eμ-Myc mouse lymphoma model, with lifespans extende...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miluzio, Annarita, Oliveto, Stefania, Pesce, Elisa, Mutti, Luciano, Murer, Bruno, Grosso, Stefano, Ricciardi, Sara, Brina, Daniela, Biffo, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741942/ https://www.ncbi.nlm.nih.gov/pubmed/26462016

Ejemplares similares

Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study
por: Scagliola, Alessandra, et al.
Publicado: (2022)

Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits
por: Pesce, Elisa, et al.
Publicado: (2020)

Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma
por: Scagliola, Alessandra, et al.
Publicado: (2021)

Sensitivity of Global Translation to mTOR Inhibition in REN Cells Depends on the Equilibrium between eIF4E and 4E-BP1
por: Grosso, Stefano, et al.
Publicado: (2011)

Preclinical Demonstration of Synergistic Active Nutrients/Drug (AND) Combination as a Potential Treatment for Malignant Pleural Mesothelioma
por: Volta, Viviana, et al.
Publicado: (2013)

Epigallocatechin-3-gallate induces mesothelioma cell death via H(2)O(2)—dependent T-type Ca(2+) channel opening
por: Ranzato, Elia, et al.
Publicado: (2012)

Identification of Overexpressed Genes in Malignant Pleural Mesothelioma
por: Morani, Federica, et al.
Publicado: (2021)

EIF4G1 and RAN as Possible Drivers for Malignant Pleural Mesothelioma
por: Dell’Anno, Irene, et al.
Publicado: (2020)

Translational Control of Metabolism and Cell Cycle Progression in Hepatocellular Carcinoma
por: Scagliola, Alessandra, et al.
Publicado: (2023)

Deregulation of miRNAs in malignant pleural mesothelioma is associated with prognosis and suggests an alteration of cell metabolism
por: De Santi, Chiara, et al.
Publicado: (2017)

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription
por: Brina, Daniela, et al.
Publicado: (2015)

PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1
por: Pinton, Giulia, et al.
Publicado: (2013)

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation
por: Manfrini, Nicola, et al.
Publicado: (2017)

Tissue expression of lactate transporters (MCT1 and MCT4) and prognosis of malignant pleural mesothelioma (brief report)
por: Dell’Anno, Irene, et al.
Publicado: (2020)

mTOR-dependent translation drives tumor infiltrating CD8(+) effector and CD4(+) Treg cells expansion
por: De Ponte Conti, Benedetta, et al.
Publicado: (2021)

Translating the Game: Ribosomes as Active Players
por: Calamita, Piera, et al.
Publicado: (2018)

MSLN Gene Silencing Has an Anti-Malignant Effect on Cell Lines Overexpressing Mesothelin Deriving from Malignant Pleural Mesothelioma
por: Melaiu, Ombretta, et al.
Publicado: (2014)

Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2
por: Miluzio, Annarita, et al.
Publicado: (2022)

A Drug Screening Revealed Novel Potential Agents against Malignant Pleural Mesothelioma
por: Dell’Anno, Irene, et al.
Publicado: (2022)

Correction: MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma
por: Melaiu, Ombretta, et al.
Publicado: (2017)

Diagnostic and Therapeutic Challenges of Malignant Pleural Mesothelioma
por: Moro, Jacopo, et al.
Publicado: (2022)

Malignant pleural mesothelioma
por: Rao, Sukhesh
Publicado: (2009)

Liquid Biopsies from Pleural Effusions and Plasma from Patients with Malignant Pleural Mesothelioma: A Feasibility Study
por: Moretti, Gabriele, et al.
Publicado: (2021)

Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma
por: Vita, Emanuele, et al.
Publicado: (2021)

Comparison of 3 Randomized Clinical Trials of Frontline Therapies for Malignant Pleural Mesothelioma
por: Meirson, Tomer, et al.
Publicado: (2022)

Malignant Pleural Mesothelioma Nodal Status: Where Are We at?
por: Ricciardi, Sara, et al.
Publicado: (2021)

Diagnostic imaging and workup of malignant pleural mesothelioma
por: Cardinale, Luciano, et al.
Publicado: (2017)

Role of microRNAs in translation regulation and cancer
por: Oliveto, Stefania, et al.
Publicado: (2017)

Malignant pleural mesothelioma with resolution of pleural effusion
por: Nishida, Sayaka, et al.
Publicado: (2023)

Reduction of estradiol in human malignant pleural mesothelioma tissues may prevent tumour growth, as implied by in in-vivo and in-vitro models
por: Nuvoli, Barbara, et al.
Publicado: (2016)

Malignant pleural mesothelioma in Italy
por: Bianchi, Claudio, et al.
Publicado: (2009)

Heterogeneity in Malignant Pleural Mesothelioma
por: Oehl, Kathrin, et al.
Publicado: (2018)

Immunotherapy in Malignant Pleural Mesothelioma
por: de Gooijer, Cornedine J., et al.
Publicado: (2020)

Malignant pleural mesothelioma: an update
por: Hajj, Glaucia N. M., et al.
Publicado: (2021)

Malignant pleural mesothelioma in situ
por: Ando, Kohei, et al.
Publicado: (2022)

Perifosine as a Potential Novel Anti-Cancer Agent Inhibits EGFR/MET-AKT Axis in Malignant Pleural Mesothelioma
por: Pinton, Giulia, et al.
Publicado: (2012)

The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells
por: Pattarozzi, Alessandra, et al.
Publicado: (2017)

MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study
por: Mozzoni, Paola, et al.
Publicado: (2017)

Ranpirnase and its potential for the treatment of unresectable malignant mesothelioma
por: Porta, Camillo, et al.
Publicado: (2008)

RACK1 Specifically Regulates Translation through Its Binding to Ribosomes
por: Gallo, Simone, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_mj6kct4uldjurgl5es34os7csq