Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy

The SGK1 kinase is pivotal in signal transduction pathways operating in cell transformation and tumor progression. Here, we characterize in depth a novel potent and selective pyrazolo[3,4-d]pyrimidine-based SGK1 inhibitor. This compound, named SI113, active in vitro in the sub-micromolar range, inhi...

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Detalles Bibliográficos
Autores principales: Talarico, Cristina, D'Antona, Lucia, Scumaci, Domenica, Barone, Agnese, Gigliotti, Francesco, Vincenza Fiumara, Claudia, Dattilo, Vincenzo, Gallo, Enzo, Visca, Paolo, Ortuso, Francesco, Abbruzzese, Claudia, Botta, Lorenzo, Schenone, Silvia, Cuda, Giovanni, Alcaro, Stefano, Bianco, Cataldo, Lavia, Patrizia, Paggi, Marco G., Perrotti, Nicola, Amato, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741945/
https://www.ncbi.nlm.nih.gov/pubmed/26462020

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