Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response

The MUS81 protein belongs to a conserved family of DNA structure-specific nucleases that play important roles in DNA replication and repair. Inactivation of the Mus81 gene in mice has no major deleterious consequences for embryonic development, although cancer susceptibility has been reported. We ha...

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Detalles Bibliográficos
Autores principales: Xing, Meichun, Wang, Xiaohui, Palmai-Pallag, Timea, Shen, Huahao, Helleday, Thomas, Hickson, Ian D., Ying, Songmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741954/
https://www.ncbi.nlm.nih.gov/pubmed/26415217

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