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SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer

A two-stage case-control study was conducted to examine the association between six candidate U2-depedent spliceosome genes (SRSF1, SRSF2, SF3A1, SF3B1, SF1 and PRPF40B) and pancreatic cancer (PC). Subjects with one or two T alleles at rs2074733 in SF3A1 had a lower risk of PC compared to those with...

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Autores principales: Tian, Jing, Liu, Yaping, Zhu, Beibei, Tian, Yao, Zhong, Rong, Chen, Wei, Lu, Xinghua, Zou, Li, Shen, Na, Qian, Jiaming, Li, Hui, Miao, Xiaoping, Wang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741962/
https://www.ncbi.nlm.nih.gov/pubmed/26498691
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author Tian, Jing
Liu, Yaping
Zhu, Beibei
Tian, Yao
Zhong, Rong
Chen, Wei
Lu, Xinghua
Zou, Li
Shen, Na
Qian, Jiaming
Li, Hui
Miao, Xiaoping
Wang, Li
author_facet Tian, Jing
Liu, Yaping
Zhu, Beibei
Tian, Yao
Zhong, Rong
Chen, Wei
Lu, Xinghua
Zou, Li
Shen, Na
Qian, Jiaming
Li, Hui
Miao, Xiaoping
Wang, Li
author_sort Tian, Jing
collection PubMed
description A two-stage case-control study was conducted to examine the association between six candidate U2-depedent spliceosome genes (SRSF1, SRSF2, SF3A1, SF3B1, SF1 and PRPF40B) and pancreatic cancer (PC). Subjects with one or two T alleles at rs2074733 in SF3A1 had a lower risk of PC compared to those with two C alleles in combined two populations (OR: 0.59, 95% confidence interval: 0.48–0.73, False discovery rate (FDR)-P = 1.5E-05). Moreover, the presence of the higher-risk genotype at rs2074733 plus smoking or drinking had synergic effects on PC risk. These findings illustrate that RNA splicing-related genes appear to be associated with the occurrence of PC, and show synergic interactions with smoking and drinking in the additive model. In the future, our novel findings should be further confirmed by functional studies and independent large-scale population studies.
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spelling pubmed-47419622016-03-17 SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer Tian, Jing Liu, Yaping Zhu, Beibei Tian, Yao Zhong, Rong Chen, Wei Lu, Xinghua Zou, Li Shen, Na Qian, Jiaming Li, Hui Miao, Xiaoping Wang, Li Oncotarget Research Paper A two-stage case-control study was conducted to examine the association between six candidate U2-depedent spliceosome genes (SRSF1, SRSF2, SF3A1, SF3B1, SF1 and PRPF40B) and pancreatic cancer (PC). Subjects with one or two T alleles at rs2074733 in SF3A1 had a lower risk of PC compared to those with two C alleles in combined two populations (OR: 0.59, 95% confidence interval: 0.48–0.73, False discovery rate (FDR)-P = 1.5E-05). Moreover, the presence of the higher-risk genotype at rs2074733 plus smoking or drinking had synergic effects on PC risk. These findings illustrate that RNA splicing-related genes appear to be associated with the occurrence of PC, and show synergic interactions with smoking and drinking in the additive model. In the future, our novel findings should be further confirmed by functional studies and independent large-scale population studies. Impact Journals LLC 2015-10-15 /pmc/articles/PMC4741962/ /pubmed/26498691 Text en Copyright: © 2015 Tian et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Tian, Jing
Liu, Yaping
Zhu, Beibei
Tian, Yao
Zhong, Rong
Chen, Wei
Lu, Xinghua
Zou, Li
Shen, Na
Qian, Jiaming
Li, Hui
Miao, Xiaoping
Wang, Li
SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
title SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
title_full SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
title_fullStr SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
title_full_unstemmed SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
title_short SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
title_sort sf3a1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741962/
https://www.ncbi.nlm.nih.gov/pubmed/26498691
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