Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties

CD133 is widely used as a surface marker to isolate cancer stem cells (CSCs). Here we show that in CSCs CD133 contributes to β-catenin-mediated transcriptional activation and to the self-renewal capacity of sphere-forming and side-population (SP) cells in cell lines from brain, colon and lung cancer...

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Detalles Bibliográficos
Autores principales: Su, Ying-Jhen, Lin, Wei-Hsin, Chang, Yi-Wen, Wei, Kuo-Chen, Liang, Chi-Lung, Chen, Shin-Cheh, Lee, Jia-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741982/
https://www.ncbi.nlm.nih.gov/pubmed/26515729

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