Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells

Bortezomib inhibits the ubiquitin/proteasome pathway to achieve its anti-cancer effect and its well characterized activity is the NF-κB inhibition through which the anti-apoptotic bcl-2 expression is down-regulated and apoptosis is subsequently induced. However, the downstream molecular targets of b...

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Detalles Bibliográficos
Autores principales: Ci, Xinyu, Li, Bingnan, Ma, Xueping, Kong, Feng, Zheng, Chengyun, Björkholm, Magnus, Jia, Jihui, Xu, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741985/
https://www.ncbi.nlm.nih.gov/pubmed/26472030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741985/
https://www.ncbi.nlm.nih.gov/pubmed/26472030

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