A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response

Broadly neutralizing antibodies targeting a highly conserved region in the hemagglutinin (HA) stem protect against influenza infection. Here, we investigate the protective efficacy of a protein (HB36.6) computationally designed to bind with high affinity to the same region in the HA stem. We show th...

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Detalles Bibliográficos
Autores principales: Koday, Merika Treants, Nelson, Jorgen, Chevalier, Aaron, Koday, Michael, Kalinoski, Hannah, Stewart, Lance, Carter, Lauren, Nieusma, Travis, Lee, Peter S., Ward, Andrew B., Wilson, Ian A., Dagley, Ashley, Smee, Donald F., Baker, David, Fuller, Deborah Heydenburg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742065/
https://www.ncbi.nlm.nih.gov/pubmed/26845438
http://dx.doi.org/10.1371/journal.ppat.1005409

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