The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence

A high proportion of human tumors maintain activation of both the PI3K and Ras/MAPK pathways. In basal-like breast cancer (BBC), PTEN expression is decreased/lost in over 50% of cases, leading to aberrant activation of the PI3K pathway. Additionally, BBC cell lines and tumor models have been shown t...

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Detalles Bibliográficos
Autores principales: Thompson, Keyata N., Whipple, Rebecca A., Yoon, Jennifer R., Lipsky, Michael, Charpentier, Monica S., Boggs, Amanda E., Chakrabarti, Kristi R., Bhandary, Lekhana, Hessler, Lindsay K., Martin, Stuart S., Vitolo, Michele I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742101/
https://www.ncbi.nlm.nih.gov/pubmed/26497685

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