The activation of EGFR promotes myocardial tumor necrosis factor-α production and cardiac failure in endotoxemia

To study the effect of EGFR activation on the generation of TNF-α and the occurrence of cardiac dysfuncetion during sepsis, PD168393 and erlotinib (both are EGFR inhibitors) were applied to decreased the production of TNF-α and phosphrylation of ERK1/2 and p38 induced by LPS in cardiomyocytes. These...

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Detalles Bibliográficos
Autores principales: Sun, Xuegang, Liang, Jiani, Yao, Xueqing, Lu, Chunhua, Zhong, Tianyu, Hong, Xiaoyang, Wang, Xiaofei, Xu, Wenjuan, Gu, Miaoning, Tang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742119/
https://www.ncbi.nlm.nih.gov/pubmed/26486084

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